Who we are

The Consortium counts on renowned research leaders in their field with international networking and project and enterprises with unique background reputation and a solid impact among researchers and professionals.

At the basic discovery level, the added value of the consortium is exceptional and counts on excellent young researchers first-time participants to FET under Horizon 2020 who proved their capability to translate visionary ideas and revolutionary materials into practice. Sound expertise on cardiac biomechanics and pathophysiology and availability of state-of- the-art technology applied to animal models and human organs as proxy of the clinical settings are ready to be implemented for the scope.

The Consortium joins academic and enterprise competence for a cross-cutting approach and effective knowledge transfer, boosting SME on polymeric materials and taking advantage of a world leading company in bioprinting to promote intersectoral mobility. Exploiting the network of a leader industry on device development regulatory processes and professionals’ involvement may allow implementing this technology to noncardiac applications beyond the consortium specialties toward a revolutionary eco-system of innovation.

The scheme below shows the main capabilities that the partners bring to REPAIR and their strong complementarity which is the base for synergic interaction.

REPAIR partners complementary capabilities in detail:

University of Florence

Italy
Background:
  • LCE material
  • Translational Cardiology
  • 3D-Bioprinting
  • EU grant coordination
Main Contributions:
  • REPAIR Coordination and management Communication and dissemination
  • Basic Research: LCE development and optimization Characterization of artificial
  • Translational Research: Optimization and refining of all LCE-based devices
Leader:
Elisabetta Cerbai, Camilla Parmeggiani, Cecilia Ferrantini, Corrado Poggesi

Scuola Superiore Sant’Anna

Italy
Background:
  • Mini-pig model of heart biomechanics energetic and failure
Main Contributions:
  • Basic Research: Design of LCE-based devices
  • Translational Research: Acute implantation of LCE-based devices in normal and post-MI pig hearts
Leader:
Fabio Recchia

Cardiovascular Research Institute Maastricht

Netherlands
Background:
  • Goat models of atrial fibrillation and ventricular dysfunction
Main Contributions:
  • Basic Research: Design of LCE-based devices
  • Translational Research: Acute implantation of LCE-based devices to goat atrium or ventricle
Leader:
Ulrich Schotten

University of Szeged

Hungary
Background:
  • Human explanted hearts
Main Contributions:
  • Translational Research: Test of personalized devices on human Langendorff-perfused hearts
Leader:
Istvan Baczko

Delft University of Technology

Netherlands
Background:
  • μLED technology
Main Contributions:
  • Basic Research: Development and characterization of LCE light-integrated contractile units
Leader:
Kouchi Zhang

National Research Council

Italy
Background:
  • Non-linear spectroscopy
  • Optical mesoscale analysis (CLARITY)
Main Contributions:
  • Basic Research: Multi-layer assembly, Suturable LCE based artificial muscle
  • Translational Research: 3D reconstruction of cardiac organization
Leader:
Leonardo Sacconi

Centre Hospitalier Univeritaire Vaudois

Switzerland
Background:
  • Cardiosurgery
  • Electro-responsive devices, cardiomyoplasty
Main Contributions:
  • Translational Research: Optimization and refining of all LCE-based devices
Leader:
Piergiorgio Tozzi

Medtronic

Netherlands
Background:
  • R&D of cardiac devices
  • Regulatory processes
  • Pipeline to market
Main Contributions:
  • REPAIR Dissemination and exploitation
  • Basic Research LED driving and synchronicity
  • Translational Research Acute implantation of LCE-based devices to goat atrium or ventricle
Leader:
Mark Lazeroms

CELLINK AB

Sweden
Background:
  • 3D Bioprinting
Main Contributions:
  • Basic Research: Superficial functionalization of LCE devices
  • Translational Research: NMR-based 3D-printed devices for human hearts
Leader:
Itedale Namro Redwan

Specific Polymers

France
Background:
  • R&D of biocompatible polymers
  • Up-scale production
Main Contributions:
  • Basic Research: Design of LCE-based devices
  • Translational Research: Acute implantation of LCE-based devices in normal and post-MI pig hearts
Leader:
Alain Graillot